With the success of medical therapy, surgery has a very limited role in the management of peptic ulcer disease. A peptic ulcer is a sore in the lining of the stomach, where it is called a gastric ulcer, or the first part of the small intestine, called a duodenal ulcer. Pdf on may 30, 2019, monjur ahmed and others published peptic ulcer disease find, read and cite all the. Protocol for diagnosis and treatment of peptic ulcer in. Department of pharmacology and biochemistry, faculty of dental. Feb 01, 2016 this video gives an overview of the pharmacological management of peptic ulcer disease. Gi pharmacology acidpeptic diseases antiemetics inflammatory bowel disease therapies pancreatic enzyme supplements bile acid therapy chronic viral hepatitis acid peptic disease dyspepsia.
This revolution, based on advances in cellular biology, pharmacology, and health care delivery, has changed forever the treatment of this major disease. Ppt peptic ulcer disease pud pathophysiology powerpoint. Although pud is most commonly caused by helicobacter pylori infection or use of nonsteroidal anti. At presentation, the patients hemodynamic status pulse, blood pressure. Mucosal injury due to helicobacter pylori infection, nsaid use, zollingerellison syndrome multiple peptic ulcerations in stomach, duodenum and jejunum due to excess gastrin secretion by a tumor, ischemia, bile pancreatic juice reflux alcohol, smoking, copd and corticosteroids use may exacerbate peptic ulcer disease and impair healing. Approximately 11%14% of men and 8%11% of women will develop peptic ulcer disease in their lifetime. Pharmacokinetics absorption is not interfered by food can cross. The association between peptic ulcer diseases and mental hea. Drugs used in acid peptic diseases clinical uses of ppis 1. A bleeding duodenal ulcer, viewed during endoscopy. The predominant causes in the united states are infection with helicobacter pylori and use of nonsteroidal anti. One out of 175 users of nsaids in the usa will be hospitalized each year for nsaidsinduced gastrointestinal damage.
If you continue browsing the site, you agree to the use of cookies on this website. Drugs used in the treatment of peptic ulcer disease may interact with the renal system in a variety of ways. Start studying pharmacology drugs for peptic ulcer disease. Elective peptic ulcer surgery has been virtually abandoned.
A free powerpoint ppt presentation displayed as a flash slide show on id. Peptic ulcer disease symptoms, treatment, pathophysiology. Physiology of gastric acid secretion gastric acid secretion is a complex, continuous process in which multiple central and peripheral factors contribute to a common endpoint. It interferes with the integrity of gastrointestinal mucosal layer within esophagus, stomach and proximal part of small intestine, called duodenum. Schematic presentation of main pathophysiological mechanisms involved in the.
Eradication oi helicobacter pylori and peptic ulcer disease i. The association between peptic ulcer diseases and mental. Peptic ulcer disease pud pathophysiology is the property of its rightful owner. Since many agents are eliminated by renal excretion, clearance of these agents may be. Your doctor will decide the best treatment based on the cause of your peptic ulcer. Prevention of recurrence of nonsteroidal antiinflammatory drug nsaid associated gastric ulcers in patients who continue nsaid use. Nsaid associated ulcer once daily therapy eradication 2 antibiotics and ppi 714 day therapy lansoprazole 2x 20mg 19 2. In the 1980s, the number of elective operations for peptic ulcer disease dropped more than 70%, and emergent operations accounted for more than 80%.
Nonsteroidal antiinflammatory drugs and aspirin 202 1. Pharmacological treatment options peptic ulcer disaese a disease characterized by ulcers in gut mucosa exposed to gastric secretions. P h r m a c o l o g y note 3 treatment of peptic ulcer. Peptic ulcer ulcer disease is caused by peptic ulceration that involves the stomach, duodenum, and lower oesophagus. Gastrointestinal pharmacology peptic ulcer disease 25 mill. In pharmacology of histamine receptors, cr ganellin, me parsons eds. New groups of compounds with different pharmacokinetics and mechanisms of action are currently being investigated, and it is possible that they will represent an alternative to, or a substitute for, the present widely used antiulcer drugs. This protocol may be used by general practitioners, family doctors, and nurses. Stomach ulcer peptic acid disease medication pharmacology lecturio duration. In duodenal ulcer, an ulcer is present in the duodenum or the.
Peptic ulcer disease nursing care and management nurseslabs. I overview on gastrointestinal pharmacology stefano evangelista encyclopedia of life support systems eolss prize in medicine for sir james black. Peptic ulcer is a lesion of the mucosal lining of the upper gastrointestinal tract characterized by an imbalance between aggressive and protective factors of the mucosa, having h. Peptic ulcer disease pud is one of the commonest diseases seen throughout.
Peptic ulcer disease occurs with the greatest frequency in people between 40 and 60 years of age. Gastric acid physiology secretion, ulcers, acid reflux. This study aimed to investigate the association between the prevalence of peptic ulcer disease pud and mental health problems, such as severe stress, depressive mood, and suicidal ideation the populationbased crosssectional study was comprised of 14,266 subjects participating in the fourth annual korea national health and nutrition examination survey from 2007 to 2009. Pharmacology of the treatment of peptic ulcer disease. Peptic ulcer disease pud is a disease of the gastrointestinal gi tract characterized by a break in the mucosal lining of the stomach or duodenum secondary to pepsin and gastric acid secretion, this damage is greater than 5 mm in size and with a depth reaching the submucosal layer. Pancreatic enzymes 11 imbalance factors that protect against acidity factors that increase acid secretion. Antrectomy including the ulcer with a billroth i anastomosis is the treatment of choice for an antral ulcer. Pharmacology peptic ulcer disease dyspepsia gord inflammatory bowel disease irritable bowel syndrome diarrhoea constipation pancreatitis dyspepsia peptic ulcer disease dyspepsia. Gastrointestinal pharmacology antacids peptic ulcer therapy antiemetics laxatives antidiarrheal drugs gastrointestinal pharmacology acid production. Antisecretory therapy is the keystone of therapy in patients with pud.
Introduction peptic ulcer disease represents a serious medical problem. The occurrence of peptic ulcer disease is similar in men and women. Pharmacodynamics basic notes pdf ppt atropine furosimide heparin basti vamana pharmacodynamics example, pharmacodynamics basics, pharmacodynamics pdf, pharmacodynamics ppt, pharmacodynamics vs pharmacokinetics, pharmacodynamics definition nursing, pharmacodynamics slideshare. It is the presence of ulcerations in gastrointestinal tract, which is characterized by being acidic, extremely painful. For an overview of peptic ulcer disease, please take a look at the fo. Professor slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
New groups of compounds with different pharmacokinetics and mechanisms of action are currently being investigated, and it is possible that they will represent an alternative to, or a substitute for, the present widely used anti ulcer drugs. Interestingly, those at the highest risk of contracting peptic ulcer disease are those. Approximately 500,000 new cases are reported each year, with 5 million people affected in the united states alone. Peptic ulcer disease pud is defined as ulcerations and erosions that occur in the stomach and duodenum. A powerpoint presentation on peptic ulcer drugs suitable for ug mbbs. This video gives an overview of the pharmacological management of peptic ulcer disease.
In duodenal ulcers there is an oversecretion of acid whilst in gastric ulcers there is an impairment of mucosal protection rapid urease tests are considered the endoscopic diagnostic. Drug treatment of peptic ulcer disease open access ebooks. Peptic ulcer disease2 free download as powerpoint presentation. Peptic ulcer pu is defect in the gastrointestinal mucosa usually located in the stomach. Pharmacodynamics basic notes pdf ppt atropine furosimide heparin basti vamana pharmacodynamics example, pharmacodynamics basics, pharmacodynamics pdf, pharmacodynamics ppt, pharmacodynamics vs pharmacokinetics, pharmacodynamics definition.
Download as ppt, pdf, txt or read online from scribd. Protonpump inhibitors pharmacology all the facts in one place. Quizlet flashcards, activities and games help you improve your grades. Drugs used in acidpeptic diseases clinical uses of ppis 1. The treatment of peptic ulcer disease has undergone a revolution in the past. Muocosal protective agents drugs pharmacokinetic action uses side effect sucralfate. Gastrointestinal pharmacology university of california. If so, share your ppt presentation slides online with powershow. Ulcers are caused by an infection of a bacterium known as helicobacter pylori or h. It is relatively uncommon in women of childbearing age, but it has been observed in children and even in infants. Nsai, aspirin, cortisone and cytotoxic drugs cigarette smoking. Protocol for diagnosis and treatment of peptic ulcer in adults. Pharmacology of peptic ulcer disease contributors s. The stomach is an outpocket of the gastrointestinal tract in which ingested food undergoes mechanical and chemical changes that promote absorption in the small and large intestine.
Peptic ulcer disease pharmacological treatment pharmaceutical. Treatment of peptic ulcer disease involves stopping bleeding by. Helicobacter pylori hp in patients with suspected peptic ulcer disease pud. There are several types of medicines used to treat a peptic ulcer. Start studying pharmacology chapter 62 pharmacotherapy of peptic ulcer disease. Diagnosis and treatment of peptic ulcer disease and h. Pharmacology chapter 62 pharmacotherapy of peptic ulcer. Gi pharmacology diffuse mucosal inflammation limited to the colon.
Peptic ulcer disease in both types of peptic ulceration, gastric and duodenal, there is an imbalance between secretion and neutralization of secreted acid. Peptic ulcer disease is an erosion or lesion in the lining of digestive tract. Ppt gastrointestinal pharmacology powerpoint presentation. The subsequent association of h pylori with gastritis and peptic ulcer formation and the use of antibiotic regimens in conjunction. Gitu, md, florida state university college of medicine family medicine. This teachable moment examines the case of a man in his 70s who presented to the emergency department 2 weeks after discontinuation of proton pump inhibitors ppis to caution against abrupt ppi discontinuation in patients with multiple risk factors for peptic ulcer disease. Peptic ulcer disease remains a relatively common disorder despite its declining incidence. Ppis work through the irreversible inhibition of the proton pump a pump found on gastric parietal cells. A peptic ulcer disease or pud is an ulcer defined as mucosal erosions equal to or greater than 0. Pharmacodynamics basic notes pdf ppt atropine furosimide. Drugs in peptic ulcer disease handout faculty of medicine. Pharmacology drugs for peptic ulcer disease quizlet. Many drugs are similar to or have similar chemical groups to the naturally occurring chemical and have the ability to bind onto a receptor where one of two things can happen either the receptor will respond or it will be blocked.
Peptic ulcer disease usually occurs in the stomach and proximal duodenum. For example protonpump inhibitors are used in the treatment of peptic ulcer disease, nsaidassociated ulcers, gerd and the eradication of h. Because of the disruption of the normal mucosal defense, pud can provoke many symptoms and signs such as dyspepsia, abdominal pain, and hemorrhage. Sep 24, 2017 peptic ulcer disease may occur in both genders and in all ages. Peptic ulcer disease pud is one of the most common diseases affecting the gastroinestinal gi tract.
Gi pharmacology metoclopramide domperidone 2 pylori. Eradication is recommended for all helicobacter pyloripositive patients, especially those patients with an active ulcer, a documented history of a prior ulcer, or a history of ulcer. If nsaids are causing your peptic ulcer and you don. Pharmacology peptic ulcer diseasedyspepsia gord inflammatory bowel disease irritable bowel syndrome diarrhoea constipation pancreatitis dyspepsia peptic ulcer disease dyspepsia. Gastric ulcers, in the stomach, and duodenal ulcers, in the upper portion of the small intestine, occur most often.
Drug therapy in peptic ulcer disease the treatment of peptic ulcer disease has undergone a revolution in the past decade. Fortunately, integrative interventions including deglycyrrhizinated licorice dgl, zinccarnosine, and lactobacillus reuteri have powerful ulcerhealing. General and inexpensive measures like introducing healthy lifestyle, stopping smoking and taking antacids should be promoted. The possibilitiy of malignant disease should be considered in all patients over the age of 40 years who. Gastroesophageal reflux disease gerd most effective agents once or twice daily. The mortality rate for peptic ulcer disease is approximately one death per 10,000 cases. Prevalence of peptic ulcer disease in patients receiving nsaids therapy ranges between 10 and 30%, what is 10 to 30fold increase over that found in the general population. It also attaches to proteins on the surface of ulcers, such as albumin and fibrinogen, to form stable insoluble complexes. Patients with peptic ulcer disease pud should reduce psychological stress, cigarette smoking, and nonsteroidal antiinflammatory drug nsaid use and avoid foods and beverages that exacerbate ulcer symptoms.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. This chapter is a revision of the chapter on peptic ulcer disease in the 8th edition written by rosemary r. Antibiotics antisecretory agents mucosal protectants antisecretory agents that enhance mucosal defenses antacids. This revolution, based on advances in cellular biology, pharmacology, and health care delivery, has changed forever the treatment of. Americans will have an ulcer in their life most common cause 85%. Over the last several decades, the development of potent antisecretory agents h2 blockers and proton pump inhibitors and the recognition that treatment for helicobacter pylori infection can eliminate most ulcer recurrences have essentially eliminated the. Mechanism of action, pharmacology, and side effects view in chinese approach to refractory peptic ulcer disease view in chinese association between helicobacter pylori infection and duodenal ulcer view in chinese cox2 inhibitors and gastroduodenal toxicity. Pdf peptic ulcer disease pud is the erosion of stomach or. Peptic ulcer disease differs from gastritis and erosions in those ulcers. These complexes serve as protective barriers at the ulcer surface, preventing further damage from acid, pepsin, and bile. Gastric acid physiology secretion, ulcers, acid reflux and treatment. Indeed, with the introduction of ppis, the healing and cure rates have improved dramatically. Peptic ulcer disease was once the most common indication for gastric surgery but now only infrequently requires operation. A bismuth monotherapy b therapy using bismuth compounds, metronidazole flagyl, and amoxicillin amoxil polymox in combination triple therapy.